The tablet dissolution tester features a circular design that provides completely uniform water temperature. The Direct-Center™ automatic centering mechanism provides guaranteed positioning of the dissolution vessels and drive shafts for accurate dissolution tests with high reproducibility. All components are controlled by Spectra Manager™ (or CFR) for simple operation.
![](https://www.jasco-global.com/wp-content/uploads/2020/10/DT-810_R-390x480.jpg)
System Features
- Complies with GLP/GMP, and USP, EP and JP requirements
- 21 CFR Part 11 compliant
- Excellent temperature stability using a circular bath
- Uniform temperature distribution between vessels
- Easy set up and maintenance
- Direct-center vessel centering for automatic alignment of vessels and drive shafts
- Test vessels manufactured with precise tolerances for vessel dimensions
- Spectra Manager™ Suite for operation and monitoring
- Automated tablet dropping system for dosage loading
- Automatic sampling tube positioning for upper and lower positions
- Amber bath & vessels for light-sensitive samples
System Lineup
Flow System
This system integrates the DT-810 with an 8-position flow cell accessory and a UV-Vis spectrophotometer. A peristaltic pump (LH-PV3) continuously circulates sample solution between the 8 dissolution vessels and the flow cell accessory. Absorbance values are measured at user declared intervals and dissolution rates are automatically calculated. External samples can also be introduced for analysis.
![](https://www.jasco-global.com/wp-content/uploads/2020/10/DTFlow730_C-480x270.jpg)
Fraction System
This system integrates a fraction collector and the LH-PV3 pumping unit for off-line testing. As many as 12 sets of samples with a volume of 20 mL or less can be collected from each dissolution vessel at pre-set intervals. Additional flow lines for solvent refills or line flushes using internal or external volumes are available.
Fraction Flow System
This system combines the fraction collector and a flow cell installed in a UV-Vis spectrophotometer. Samples from the dissolution vessels are collected in test tubes using the fraction collector and sample aliquots are analyzed by the UV-Vis using the autosampling capability of the fraction collector. Residual sample volumes can be analyzed later using other techniques such as HPLC.
![](https://www.jasco-global.com/wp-content/uploads/2020/10/DTFractionFlow_C-480x215.jpg)
Automated Filtration System
This system includes the LH-SV8 8-position syringe pump and the AF-801 Automated filter changer. It provides automatic filtration of a maximum of 20 ml of sample solutions from all 8 vessels using 25 mm diameter membrane filters with a pore size of 0.45 micron (0.2 micron-optional). After each sampling, filters are automatically exchanged. The dedicated software can fully automate the dissolution testing including sample filtering.
![](https://www.jasco-global.com/wp-content/uploads/2020/10/DTFiltration730_Cpk-480x195.jpg)