Author
Miyu Nakano, Masato Urabe, Naishu Yang, Yuta Nakayasu, Yuya Hiraga, Research Center of Supercritical Fluid Technology, Graduate School of Engineering, Tohoku University Hiroyuki Komatsu, Graduate School of Science and Technology, Niigata University Masaki Ota, Research Center of Supercritical Fluid Technology, Graduate School of Engineering, Graduate School of Environmental Studies, Tohoku University
Keywords
Supercritical fluid chromatography (SFC), Mobile phase, Stationary phase, Modifier, Distribution (Partition) coefficient, Carbon dioxide
Abstract
A new switchable chromatography and break-through curve calculation method was developed. We introduced the latest research results, focusing on the history of theoretical development of chromatography calculation models based on thermodynamics and chemical engineering, and their verification results. It would be useful to be able to express the affinity between the stationary phase and the mobile phase by reducing it to the SP value or entropy-based solubility parameter (eSP) value of the solute, and we have begun creating a database and theorizing the distribution coefficient (KSolute). At present, controlling this KSolute value is essential in chiral separations where solutes have the same physical properties. Finally, by switching the impulse input to a step input in the advection-equilibrium stage model, it is possible to switch from the chromatogram to the depiction of the breakthrough curve. In this way, another feature of this model is that it is switchable when the input method is changed.